Prof. Wu’s interdisciplinary research advances equitable healthy aging at the individual, family, and societal levels through a precision public health framework, with three core directions: (1) Investigating frailty—a heterogeneous, dynamic geriatric syndrome driving late-life health inequalities—to develop targeted interventions preserving independence, easing family caregiving, and reducing societal healthcare burden; (2) Designing scalable, personalized prevention strategies using digital tools, big data analytics, and technological innovations to translate research into actionable outcomes for individuals, families, and communities; and (3) Exploring gene-lifestyle-social/natural environment interplay to address health disparities and advance context-specific, person-centered precision aging strategies globally.